Intravenous Immunoglobulin for the Treatment of Severe Maternal Alloimmunization: Individual Patient Data Meta-Analysis.

OBJECTIVE: To investigate the outcomes associated with the administration of maternal intravenous immunoglobulin (IVIG) in high-risk red blood cell (RBC) alloimmunized pregnancies. DATA SOURCES: We systematically searched Medline, Embase, and Cochrane Library until June 2023. STUDY ELIGIBILITY CRITERIA: We included studies reporting on pregnancies with severe RBC alloimmunization, defined as either a previous fetal or neonatal death or the need for IUT before 24 weeks in the previous pregnancy as a result of hemolytic disease of fetus and newborn (HDFN). STUDY APPRAISAL AND SYNTHESIS METHODS: Cases were pregnancies that received IVIG, while controls did not. Individual patient data (IPD) meta-analysis was performed using the Bayesian framework. RESULTS: IPD analysis included eight studies comprising 97 cases and 97 controls. IVIG was associated with prolonged delta GA at first IUT (GA of current pregnancy - GA at prior pregnancy) (Mean Difference (MD): 3.19 weeks, 95% CrI 1.28, 5.05), prolonged GA at first IUT (MD: 1.32 weeks, 95% CrI 0.08, 2.5), reduced risk of fetal hydrops at time of first IUT (Incidence Rate Ratio (IRR): 0.19, 95% CrI 0.07, 0.45), reduced risk of fetal demise (IRR: 0.23, 95% CrI 0.10, 0.47), higher chances of live birth ≥28 weeks, ≥32 weeks, and survival at birth (IRR: 1.88, 95% CrI 1.31, 2.69; IRR: 1.93, 95% CrI 1.32, 2.83; IRR: 1.82, 9% CrI 1.30 to 2.61, respectively). There were no significant differences in numbers of IUT, hemoglobin level at birth, bilirubin level at birth, or survival at hospital discharge for live births. CONCLUSION: IVIG treatment in pregnancies at risk of severe early HDFN seems to have a clinically relevant beneficial effect on the course and severity of the disease.

Genital Self-Image, Sexual Function, and Quality of Life Among Individuals with Vulvar and Non-Vulvar Inflammatory Dermatoses.

Vulvar inflammatory dermatoses (VID; e.g., lichen sclerosus, lichen planus, vulvar dermatitis) can significantly impact sexual function. Both vulvar and non-vulvar inflammatory dermatoses (NVID; i.e., skin conditions not impacting vulvar skin, such as non-genital psoriasis and eczema/dermatitis) have yet to be fully characterized with regard to impact on genital self-image. A 20-min web-based survey was distributed September-November 2020 through social media ads, support groups, and online research recruitment services. Individuals in the USA over age 18 who were assigned female at birth and self-reported having been diagnosed with an inflammatory dermatosis were eligible. The primary outcome was the Female Genital Self-Image Scale (FGSIS). Secondary outcomes included the Female Sexual Function Index (FSFI), the Skindex-16 (a skin-related quality of life measure), the PROMIS Global-10 (assessing global physical/mental health), and sexual behavior histories. Participants (n = 348) reported mean age of 43.1 ± 15.5 (range = 19-81). Nearly one-third (n = 101; 29.0%) reported VID, 173 (50%) had NVID, and 74 (21%) experienced both vulvar and non-vulvar symptoms; they were analyzed as part of the VID group. The mean FGSIS score among participants with VID was 16.9 ± 4.1 and was significantly (p < .01) lower than that of participants with NVID (M = 21.2 ± 4.3), indicating lower genital self-image. Mental health (as measured by PROMIS-Global 10) was also impaired in VID. Rates of sexual dysfunction were high in both groups (> 60%). Findings suggest that in VID, lower genital self-image is correlated with poorer sexual function, quality of life, and global physical and mental health. Additional recommendations for VID management are proposed.

"Worse Than Disappointing": Prediagnostic Health Care Challenges of Women With Inflammatory Vulvar Dermatoses.

OBJECTIVE: The purpose of this study was to investigate challenges women face before inflammatory vulvar dermatosis diagnosis to guide interventions for improving time to diagnosis and health care experiences. MATERIALS AND METHODS: The present analysis was part of a larger study exploring sexual health and quality of life of women with vulvar and nonvulvar inflammatory dermatoses, evaluated via a 20-minute web-based survey. One open-response item asked participants to "briefly describe any challenges you faced with regards to health care or health care providers in the time when you were seeking a diagnosis"; this item informed the present study. Eligible participants were women older than 18 years, living in the United States, with diagnosis of an inflammatory vulvar dermatosis persisting at least 1 month. Participants (n = 118) had a mean age of 46.55 ± 15.35 years, and 64% (n = 75) had lichen sclerosus. RESULTS: Provider-based challenges consisted of insensitive communication and ascribing physical symptoms to mental health issues, self-harm, or other factors. System-based challenges included confusing referral networks, limited specialist access, and widespread lack of provider education. Personal challenges for participants seeking care included feelings of embarrassment and reduced health care efficacy. Challenges led to emotional response and impact for participants, characterized by negative (e.g., distrust in the medical system) or positive (e.g., self-advocacy efforts, strong social media communities) outcomes. CONCLUSIONS: Findings provide unique insights into the challenges women experience before inflammatory vulvar dermatosis diagnosis. This study creates new knowledge exploring the diagnostic journey accompanying inflammatory vulvar dermatoses and contributes practically to clinical and research needs of this understudied population.

The use of hand grip strength as a predictor of nutrition status in hospital patients.

BACKGROUND & AIMS: Hand grip strength (HGS) has been found to respond to nutrition deprivation and repletion but few studies have investigated its use as an independent nutrition assessment tool. We conducted an observational study to determine if HGS can predict nutrition status independently of other factors. METHODS: The Patient Generated Subjective Global Assessment (PG-SGA) was used to determine nutrition status. PG-SGA and HGS measures were collected from 217 well nourished and malnourished hospital patients for cross-sectional analysis. Of the 217, 18 patients had these assessments repeated two weeks (±3 days) later to assess change. Correlation, and multiple linear and binary regression analyses were conducted. RESULTS: HGS and PG-SGA score were significantly correlated (r = 0.292, P < 0.01). HGS was a significant independent predictor of PG-SGA score and category (P < 0.01), accounting for 4% and 9% of variability respectively. Change-in-HGS was an independent predictor of change-in-PG-SGA score (P = 0.04) and category (P = 0.06) over two weeks, accounting for 47% and 42% of variability respectively. CONCLUSIONS: Our results suggest that HGS can independently predict nutrition status and change in nutrition status defined by PG-SGA score and category, although future longer term research is required to confirm the use of HGS as an early detection tool for malnutrition risk.